Description

4-(1-Amino-2,2,2-Trifluoro-Ethyl)-Benzoic Acid Hydrochloride is a high-purity, trifluoromethylated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where the introduction of the trifluoromethyl group is crucial for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules with enhanced properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the creation of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of specialty polymers and advanced organic materials with unique electronic or surface properties.
• Chemical Biology Probe Synthesis: Utilized to create labeled compounds or molecular probes for studying biological mechanisms and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	4-(1-Amino-2,2,2-Trifluoro-Ethyl)-Benzoic Acid Hydrochloride
CAS No.	1965309-68-5
Molecular Formula	C9H9F3NO2 • HCl
Molecular Weight	259.63 g/mol
Synonyms	4-(1-Amino-2,2,2-trifluoroethyl)benzoic acid hydrochloride; 4-(Aminotrifluoroethyl)benzoic acid HCl; Benzoic acid, 4-(1-amino-2,2,2-trifluoroethyl)-, hydrochloride; α-(Trifluoromethyl)-4-aminomethylbenzoic acid hydrochloride; 4-(2,2,2-Trifluoro-1-aminoethyl)benzoic acid hydrochloride; (4-Carboxyphenyl)(trifluoromethyl)methylamine hydrochloride; TFMP Benzoic Acid Derivative HCl Salt
EINECS	Contact for details

Quality Control

Our 4-(1-Amino-2,2,2-Trifluoro-Ethyl)-Benzoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.