Description

(S)-1,2,3,4-Tetrahydro-Quinolin-4-Ylamine Dihydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, enabling the creation of novel therapeutic agents with specific stereochemistry. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to construct stereogenic centers.
• Medicinal Chemistry Research: A versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Process Chemistry: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Chemical Biology: Can be incorporated into molecular probes for studying enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-Quinolin-4-Ylamine Dihydrochloride
CAS No.	1965305-30-9
Molecular Formula	C9H14Cl2N2
Molecular Weight	221.13 g/mol
Synonyms	(4S)-1,2,3,4-Tetrahydroquinolin-4-amine dihydrochloride; (S)-4-Amino-1,2,3,4-tetrahydroquinoline dihydrochloride; (S)-Tetrahydroquinolin-4-amine dihydrochloride; (S)-THQ-4-amine 2HCl; (S)-4-ATQ dihydrochloride; (S)-1,2,3,4-Tetrahydro-4-quinolinamine dihydrochloride; (S)-4-Aminotetrahydroquinoline dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydro-Quinolin-4-Ylamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.