Description

(1R,3R)-3-Fluorocyclopentan-1-Amine Hydrochloride CAS NO 1958100-47-4 is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting neurological and metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of advanced therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore fluorinated cyclopentane scaffolds.
• Asymmetric Synthesis: Serves as a valuable chiral amine source for the construction of complex, enantiomerically pure molecules.
• Proteolysis Targeting Chimera (PROTAC) Development: Can be incorporated as a linker component or targeting ligand in bifunctional degrader molecules.
• Agrochemical Research: Potential intermediate for developing advanced, fluorinated active ingredients with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for asymmetric catalysis and metal complexes.

Basic Information

Product Name	(1R,3R)-3-Fluorocyclopentan-1-Amine Hydrochloride
CAS No.	1958100-47-4
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol (Free base: C5H10FN, 103.14 g/mol)
Synonyms	(1R,3R)-3-Fluorocyclopentanamine Hydrochloride; (1R,3R)-3-Fluorocyclopentylamine HCl; rel-(1R,3R)-3-Fluorocyclopentan-1-amine Hydrochloride; (1R,3R)-3-Fluoro-1-cyclopentanamine Hydrochloride; 3-Fluoro-cis-cyclopentylamine Hydrochloride; cis-3-Fluorocyclopentylamine Hydrochloride; (1R,3R)-3-Fluorocyclopentylamine Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our (1R,3R)-3-Fluorocyclopentan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research-grade and pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.