Description

tert-Butyl 6,8-Dichloro-3,4-Dihydro-2,7-Naphthyridine-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its naphthyridine core structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and antiviral research domains.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting specific enzyme inhibitors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• API Development: Used in the research and development phase for creating potential new active pharmaceutical ingredients with a naphthyridine backbone.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	tert-Butyl 6,8-Dichloro-3,4-Dihydro-2,7-Naphthyridine-2(1H)-Carboxylate
CAS No.	1956331-16-0
Molecular Formula	C₁₃H₁₄Cl₂N₂O₂
Molecular Weight	301.17 g/mol
Synonyms	2,7-Naphthyridine-2(1H)-carboxylic acid, 6,8-dichloro-3,4-dihydro-, 1,1-dimethylethyl ester; 6,8-Dichloro-1,2,3,4-tetrahydro-2,7-naphthyridine-2-carboxylic acid tert-butyl ester; tert-Butyl 6,8-dichloro-1,2,3,4-tetrahydro-2,7-naphthyridine-2-carboxylate; BOC-6,8-Dichloro-1,2,3,4-tetrahydro-2,7-naphthyridine-2-carboxylate; 1956331-16-0; 6,8-Dichloro-3,4-dihydro-2H-2,7-naphthyridine-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6,8-Dichloro-3,4-Dihydro-2,7-Naphthyridine-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and cGMP applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.