Description

1,1-Difluorospiro[2.3]Hexan-5-Amine Hydrochloride is a high-value, spirocyclic amine derivative featuring a difluorinated structure, making it a critical building block in advanced organic synthesis. Its unique scaffold is prized for introducing conformational rigidity and modulating physicochemical properties in target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and metabolic disease therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides, where the difluorospiro structure can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials with specific fluorinated properties.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated spirocyclic architectures.

Basic Information

Product Name	1,1-Difluorospiro[2.3]Hexan-5-Amine Hydrochloride
CAS No.	1955540-34-7
Molecular Formula	C7H12ClF2N
Molecular Weight	183.63 g/mol
Synonyms	5-Amino-1,1-difluorospiro[2.3]hexane hydrochloride; 1,1-Difluoro-5-aminospiro[2.3]hexane HCl; Spiro[2.3]hexan-5-amine, 1,1-difluoro-, hydrochloride; 1955540-34-7; 1,1-Difluorospiro[2.3]hexan-5-amine HCl salt; 5-Amino-1,1-difluorospiro[2.3]hexane HCl salt; Difluorospirohexylamine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 1,1-Difluorospiro[2.3]Hexan-5-Amine Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity, meeting the stringent requirements for advanced R&D and scale-up. Certificates of Analysis (COA) with full analytical data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.