Description

1,1-Difluorospiro[2.5]Octan-6-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated molecular architecture. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily needed by R&D and process development teams within the pharmaceutical and agrochemical industries for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the spirocycle and fluorine motifs, which are prized for modulating lipophilicity and conformation.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents, leveraging its structural complexity for novel modes of action.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for investigating biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A specialized material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	1,1-Difluorospiro[2.5]Octan-6-Amine Hydrochloride
CAS No.	1955530-17-2
Molecular Formula	C8H14ClF2N
Molecular Weight	197.65 g/mol
Synonyms	6-Amino-1,1-difluorospiro[2.5]octane hydrochloride; 1,1-Difluoro-6-aminospiro[2.5]octane HCl; Spiro[2.5]octan-6-amine, 1,1-difluoro-, hydrochloride; 1955530-17-2; 1,1-Difluorospirooctan-6-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 1,1-Difluorospiro[2.5]Octan-6-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.