Description

6-Bromo-2-(Chloromethyl)Quinazoline is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic reactivity of both the bromo and chloromethyl substituents, enabling precise molecular construction for complex target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel quinazoline-based active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other biologically active quinazoline derivatives.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that utilize the quinazoline scaffold.
• Material Science Research: Serves as a building block for creating organic ligands, functional polymers, or advanced organic electronic materials.
• Chemical Biology Probes: Employed in the development of molecular probes and tags for studying biological processes due to its modifiable reactive sites.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck).
• Nucleophilic Substitution: The chloromethyl group is reactive towards various nucleophiles, allowing for side-chain diversification and linker attachment.

Basic Information

Product Name	6-Bromo-2-(Chloromethyl)Quinazoline
CAS No.	1936538-67-8
Molecular Formula	C9H6BrClN2
Molecular Weight	257.51 g/mol
Synonyms	2-(Chloromethyl)-6-bromoquinazoline; 6-Bromo-2-chloromethylquinazoline; Quinazoline, 6-bromo-2-(chloromethyl)-; 6-Bromo-2-(chloromethyl)-1,3-diazanaphthalene
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-(Chloromethyl)Quinazoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC), and impurity profiles is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.