Description

3-Aminobicyclo[1.1.1]pentan-1-ol is a high-value, structurally constrained bicyclic building block featuring both amino and hydroxyl functional groups. This unique scaffold is critical for medicinal chemistry and drug discovery, enabling the synthesis of novel bioactive compounds with improved metabolic stability and three-dimensional character. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for applications in fragment-based drug design and the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for constructing sp3-rich, conformationally restricted analogs in drug discovery programs.
• Bioisostere Development: Used to replace traditional phenyl or tert-butyl groups to modulate physicochemical properties like solubility and lipophilicity.
• Peptidomimetics: Serves as a constrained scaffold in the design of peptide mimics to enhance proteolytic stability.
• Agrochemical Research: Employed in the synthesis of novel active ingredients with potential herbicidal or insecticidal activity.
• Ligand Synthesis for Catalysis: Useful for creating novel chiral ligands and organocatalysts due to its rigid, three-dimensional structure.
• Material Science Precursor: Potential monomer or cross-linking agent for specialty polymers with unique thermal or mechanical properties.

Basic Information

Product Name	3-Aminobicyclo[1.1.1]pentan-1-ol
CAS No.	1936222-91-1
Molecular Formula	C5H9NO
Molecular Weight	99.13 g/mol
Synonyms	1-Amino-3-hydroxybicyclo[1.1.1]pentane; 3-Amino-1-hydroxybicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentan-1-ol, 3-amino-; 3-Aminobicyclo[1.1.1]pentanol; 1-Hydroxy-3-aminobicyclo[1.1.1]pentane; 3-Amino-BCP-ol; Aminohydroxybicyclopentane
EINECS	Contact for details

Quality Control

Our 3-Aminobicyclo[1.1.1]pentan-1-ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. We provide a Certificate of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure it meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.