Description

2-Chloro-4-(Fluorosulfonyl)Benzoic Acid is a high-value, multi-functional aromatic building block of significant interest in advanced organic synthesis. Its unique structure, combining a carboxylic acid, a sulfonyl fluoride, and a chloro substituent, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with potential for improved efficacy and selectivity.
• Chemical Biology Probe Development: The sulfonyl fluoride group enables its use in activity-based protein profiling (ABPP) and the creation of covalent inhibitors for target identification and validation.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialized polymers, such as polyelectrolytes or sulfonated materials for membrane applications.
• Organic Synthesis Reagent: Utilized in Suzuki-Miyaura and other cross-coupling reactions to introduce the benzoic acid scaffold into more complex molecular architectures.
• Fluorination Chemistry: Acts as a source of the -SO2F group for introducing the fluorosulfonyl moiety into target molecules, a valuable functional group in medicinal chemistry.

Basic Information

Product Name	2-Chloro-4-(Fluorosulfonyl)Benzoic Acid
CAS No.	1934852-61-5
Molecular Formula	C7H4ClFO4S
Molecular Weight	238.62 g/mol
Synonyms	2-Chloro-4-fluorosulfonylbenzoic acid; 4-(Fluorosulfonyl)-2-chlorobenzoic acid; Benzoic acid, 2-chloro-4-(fluorosulfonyl)-; 2-Chloro-4-fluorosulfonyl-benzoic acid; 2-Chloro-4-sulfonylfluorobenzoic acid; 4-Fluorosulfonyl-2-chlorobenzoic acid; 2-Chloro-4-fluorosulfonyl benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(Fluorosulfonyl)Benzoic Acid is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.