Description

(1R,2R)-2-Aminocyclobutanol Hydrochloride is a high-purity chiral building block essential for advanced pharmaceutical synthesis. Its rigid cyclobutane scaffold and functionalized amine and alcohol groups make it a valuable intermediate for constructing complex molecules with defined stereochemistry. This compound is primarily utilized by research institutions and pharmaceutical companies in the development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, including protease inhibitors and other small molecule therapeutics.
• Asymmetric Synthesis: Serves as a precursor for chiral ligands, catalysts, or auxiliaries used in stereoselective chemical transformations.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical space and optimize pharmacological properties.
• Peptidomimetics: The constrained cyclobutane ring can be incorporated to mimic peptide backbones, enhancing metabolic stability and bioavailability.
• Chemical Biology Probes: Functionalization of the amine and alcohol groups allows for the creation of molecular probes for studying biological pathways.

Basic Information

Product Name	(1R,2R)-2-Aminocyclobutanol Hydrochloride
CAS No.	1909287-71-3
Molecular Formula	C4H10ClNO
Molecular Weight	123.58 g/mol
Synonyms	(1R,2R)-2-Aminocyclobutane-1-ol hydrochloride; trans-2-Aminocyclobutanol hydrochloride; (1R,2R)-1-Amino-2-hydroxycyclobutane hydrochloride; Cyclobutanol, 2-amino-, hydrochloride, (1R,2R)-; (1R,2R)-2-Azanylcyclobutan-1-ol;hydrochloride
EINECS	Contact for details

Quality Control

Our (1R,2R)-2-Aminocyclobutanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.