Description

Cyclobutanamine, 2-(Methoxymethyl)-, Hydrochloride (1:1), (1R,2R)- is a high-purity, chiral building block of significant interest in advanced pharmaceutical synthesis. This compound matters because its defined stereochemistry and functionalized cyclobutane ring make it a valuable intermediate for constructing complex, three-dimensional molecular architectures with potential biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and therapeutic candidates. The CAS number for this specific stereoisomer is 1909287-01-9.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Advanced Organic Synthesis: Used as a constrained, functionalized building block to introduce the cyclobutane scaffold into complex molecules, exploring structure-activity relationships (SAR).
• Medicinal Chemistry Research: Employed in the synthesis of compound libraries for high-throughput screening (HTS) to identify new lead structures.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for target molecules under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in stereoselective transformations due to its defined (1R,2R) configuration, enabling the construction of enantiomerically pure compounds.

Basic Information

Product Name	Cyclobutanamine, 2-(Methoxymethyl)-, Hydrochloride (1:1), (1R,2R)-
CAS No.	1909287-01-9
Molecular Formula	C6H14ClNO
Molecular Weight	151.63 g/mol
Synonyms	(1R,2R)-2-(Methoxymethyl)cyclobutanamine hydrochloride; (1R,2R)-2-(Methoxymethyl)cyclobutylamine hydrochloride; (1R,2R)-2-(Methoxymethyl)cyclobutan-1-amine hydrochloride; (1R,2R)-Aminomethyl methoxy cyclobutane hydrochloride; trans-2-(Methoxymethyl)cyclobutanamine hydrochloride; Chiral cyclobutylamine hydrochloride derivative; (1R,2R)-Methoxymethylcyclobutylamine HCl
EINECS	Contact for details

Quality Control

Our Cyclobutanamine, 2-(Methoxymethyl)-, Hydrochloride (1:1), (1R,2R)- is manufactured under strict quality control protocols to ensure high chemical and chiral purity suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry-standard analytical methods, and specifications can be tailored to meet specific project requirements, including those for GMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.