Description

Aminooxy-Peg3-Bromide is a heterobifunctional polyethylene glycol (PEG) linker featuring an aminooxy group and a terminal bromide. This compound is engineered to facilitate the site-specific conjugation of biomolecules, offering a valuable tool for creating stable oxime linkages. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced material science. The product is supplied under strict quality control to ensure batch-to-batch consistency for critical applications.

Application

• Bioconjugation Reagent: For the site-specific coupling of aldehydes or ketones to proteins, antibodies, or peptides via stable oxime bond formation.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component for constructing homogeneous, next-generation ADCs with controlled drug-to-antibody ratios.
• PEGylation Chemistry: Used to introduce a hydrophilic PEG spacer to drug molecules or surfaces, improving solubility and pharmacokinetic properties.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and other material surfaces with bioactive molecules.
• Cross-linking Agent: Acts as a heterobifunctional cross-linker for coupling two different molecules, one via the aminooxy group and the other via nucleophilic substitution of the bromide.
• Proteomics Research: A tool for chemical labeling and enrichment strategies in mass spectrometry-based proteomic studies.
• Hydrogel Formation: Can be employed as a building block in the synthesis of PEG-based hydrogels for tissue engineering and drug delivery systems.

Basic Information

Product Name	Aminooxy-Peg3-Bromide
CAS No.	1895922-73-2
Molecular Formula	C11H22BrN2O5
Molecular Weight	333.21 g/mol
Synonyms	1-Aminooxy-3,6,9-trioxa-12-azatetradec-13-yl bromide; 2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethyloxyamine; Bromo-PEG3-aminooxy; O-(2-Aminooxyethyl)-O'-(2-bromoethyl)triethylene glycol; Aminooxy-PEG3-Br; Aminooxy-PEG3-alkyl bromide; 13-Bromo-3,6,9-trioxa-12-azatetradecan-1-oxime
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg3-Bromide is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and consistency. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) with detailed specifications are provided for every lot. We support development and cGMP-grade manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C under an inert atmosphere (argon or nitrogen) due to its sensitivity to oxidation and moisture. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.