Description

Spiro[1H-Indene-1,5'-Oxazolidine]-2',4'-Dione, 5-Bromo-2,3-Dihydro-3-Hydroxy-, (1R,3R)- is a high-purity, stereochemically defined spirocyclic compound that serves as a critical chiral building block in advanced organic synthesis. Its unique fused-ring structure and specific stereochemistry make it invaluable for constructing complex molecular architectures with precise three-dimensional control. This intermediate is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Utilized as a sophisticated building block to introduce stereogenic centers and complex ring systems in target molecules via advanced synthetic routes.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Process Chemistry Development: Serves as a pivotal intermediate in scaling up synthetic pathways from laboratory to pilot and commercial production scales.
• Fine Chemical Production: Used in the manufacture of high-value specialty chemicals, including agrochemicals, flavors, and fragrances requiring specific chirality.
• Academic & Industrial R&D: A valuable compound for methodological development in organic synthesis and catalysis within research institutions.

Basic Information

Product Name	Spiro[1H-Indene-1,5'-Oxazolidine]-2',4'-Dione, 5-Bromo-2,3-Dihydro-3-Hydroxy-, (1R,3R)-
CAS No.	1889291-54-6
Molecular Formula	C11H8BrNO4
Molecular Weight	298.09 g/mol
Synonyms	(1R,3R)-5-Bromo-2,3-dihydro-3-hydroxyspiro[1H-indene-1,5'-oxazolidine]-2',4'-dione; 5-Bromo-3-hydroxy-2,3-dihydrospiro[indene-1,5'-oxazolidine]-2',4'-dione (1R,3R)-; (1R,3R)-5-Bromo-3-hydroxy-2,3-dihydro-1H-spiro[indene-1,5'-oxazolidine]-2',4'-dione; Spiro[indene-oxazolidinedione] derivative; Bromo-hydroxy spirooxazolidinedione; (1R,3R)-enantiomer of CAS 1889291-54-6. Contact for additional aliases.
EINECS	Contact for details

Quality Control

Our production of Spiro[1H-Indene-1,5'-Oxazolidine]-2',4'-Dione, 5-Bromo-2,3-Dihydro-3-Hydroxy-, (1R,3R)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized and released with a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral purity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can provide materials meeting specific customer specifications for advanced R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1R,3R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.