Description

(R)-5'-Bromo-2',3'-Dihydrospiro[Imidazolidine-4,1'-Indene]-2,5-Dione is a high-purity, chiral spirocyclic compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical R&D, agrochemical research, and specialized fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and develop new bioactive molecules.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective chemical transformations to introduce complex molecular architecture.
• Agrochemical Development: Potential use in the research and synthesis of new, high-efficacy crop protection agents.
• Chemical Biology Probes: Useful for creating specialized probes to study enzyme function and biological pathways.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of synthetic routes for target molecules.

Basic Information

Product Name	(R)-5'-Bromo-2',3'-Dihydrospiro[Imidazolidine-4,1'-Indene]-2,5-Dione
CAS No.	1889290-54-3
Molecular Formula	C11H9BrN2O2
Molecular Weight	281.11 g/mol
Synonyms	(R)-5'-Bromo-2,3-dihydrospiro[imidazolidine-4,1'-indene]-2,5-dione; (5'R)-5'-Bromo-2',3'-dihydrospiro[imidazolidine-4,1'-indene]-2,5-dione; 1889290-54-3; (R)-5'-Bromospiro[imidazolidine-4,1'-indene]-2,5-dione; Spiro[imidazolidine-4,1'-indene]-2,5-dione, 5'-bromo-2',3'-dihydro-, (5'R)-; (R)-enantiomer of 5'-Bromo-2',3'-dihydrospiro[imidazolidine-4,1'-indene]-2,5-dione
EINECS	Contact for details

Quality Control

Every batch of (R)-5'-Bromo-2',3'-Dihydrospiro[Imidazolidine-4,1'-Indene]-2,5-Dione is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity, chemical purity, and residual solvents. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.