Description

n-Methylbicyclo[1.1.1]pentan-1-amine hydrochloride is a high-value, structurally constrained amine hydrochloride salt, serving as a critical building block in modern organic synthesis. Its unique [1.1.1]propellane-derived bicyclic framework offers significant value for creating novel molecular architectures with enhanced physicochemical properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, chemical biology, and materials science.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry: Used as a rigid, sp3-rich bioisostere to replace linear or flexible amine moieties, improving potency, selectivity, and metabolic stability in drug candidates.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds and probes to study enzyme function and protein-protein interactions.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Materials Science: Building block for specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Academic & Industrial R&D: Fundamental research reagent for exploring new synthetic methodologies and reaction pathways involving strained bicyclic systems.

Basic Information

Product Name	n-Methylbicyclo[1.1.1]pentan-1-amine Hydrochloride
CAS No.	1886967-09-4
Molecular Formula	C7H14ClN
Molecular Weight	147.64 g/mol
Synonyms	1-Amino-1-methylbicyclo[1.1.1]pentane hydrochloride; 1-Methylbicyclo[1.1.1]pentan-1-amine hydrochloride; Bicyclo[1.1.1]pentan-1-amine, 1-methyl-, hydrochloride; Methyl[1.1.1]propellan-1-amine hydrochloride; [1.1.1]Propellane-1-methylamine hydrochloride
EINECS	Contact for details

Quality Control

Our n-Methylbicyclo[1.1.1]pentan-1-amine hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.