Description

3-Isopropylbicyclo[1.1.1]pentan-1-amine hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its unique, rigid bicyclo[1.1.1]pentane (BCP) scaffold, which serves as a bioisostere for *para*-substituted benzene rings and alkynes, offering improved metabolic stability and physicochemical properties in drug design. It is primarily utilized by medicinal chemists and process development scientists in the research and synthesis of novel therapeutic agents, particularly within the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Medicinal Chemistry & Drug Discovery: Used as a sp3-rich bioisostere to replace flat aromatic rings or linear alkynes, enhancing solubility, reducing lipophilicity, and improving the drug-like properties of candidate molecules.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides, where the BCP core can contribute to unique biological activity and patentability.
• Material Science & Polymer Chemistry: Serves as a functional monomer or cross-linking agent for creating polymers with tailored mechanical and thermal properties.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Incorporated into linker designs or warhead components for targeted protein degradation platforms.
• Academic & Contract Research: Used in fundamental research exploring new chemical space and reaction methodologies involving strained cage structures.

Basic Information

Product Name	3-Isopropylbicyclo[1.1.1]pentan-1-amine hydrochloride
CAS No.	1886967-00-5
Molecular Formula	C8H16ClN
Molecular Weight	161.67 g/mol
Synonyms	1-Amino-3-isopropylbicyclo[1.1.1]pentane hydrochloride; 3-Isopropyl-BCP-amine HCl; 3-(Propan-2-yl)bicyclo[1.1.1]pentan-1-amine hydrochloride; BCP-NH2·HCl (isopropyl substituted); 1-Bicyclo[1.1.1]pentanamine, 3-(1-methylethyl)-, hydrochloride; 3-Isopropyl-1-aminobicyclo[1.1.1]pentane hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Isopropylbicyclo[1.1.1]pentan-1-amine hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications in GLP and cGMP environments, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.