Description

2(1H)-Quinolinone, 8-Fluoro-5-Hydroxy- is a high-purity fluorinated quinolinone derivative, serving as a critical advanced pharmaceutical intermediate and a versatile scaffold for medicinal chemistry research. Its unique fluorinated hydroxyquinoline structure makes it a valuable building block for developing novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for synthesis and screening applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Scaffold: Core structure for constructing compound libraries in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Fluorinated Building Block: Essential for introducing fluorine atoms into target molecules to modulate their physicochemical and pharmacokinetic properties.
• Agrochemical Research: Intermediate in the development of new-generation pesticides and herbicides.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced organic electronic materials.

Basic Information

Product Name	2(1H)-Quinolinone, 8-Fluoro-5-Hydroxy-
CAS No.	1883750-00-2
Molecular Formula	C9H6FNO2
Molecular Weight	179.15 g/mol
Synonyms	8-Fluoro-5-hydroxyquinolin-2(1H)-one; 8-Fluoro-5-hydroxy-1,2-dihydroquinolin-2-one; 5-Hydroxy-8-fluoro-2(1H)-quinolinone; 8-Fluoro-5-hydroxy-2-quinolinone; 5-Hydroxy-8-fluoroquinolin-2(1H)-one; 8-Fluoro-5-hydroxy-1H-quinolin-2-one; 8-Fluoro-5-hydroxycarbostyril
EINECS	Contact for details

Quality Control

Our 2(1H)-Quinolinone, 8-Fluoro-5-Hydroxy- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.