Description

3‐Hydroxy‐1',2'‐Dihydrospiro[Cyclobutane‐1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic architecture. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted small-molecule drug candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker-warhead conjugates due to its unique three-dimensional structure and functional handles.
• Kinase Inhibitor Synthesis: Employed in the development of novel kinase inhibitors, leveraging the pyrrolopyridine core which is prevalent in many kinase-binding motifs.
• Chemical Biology Probes: Utilized to create specialized molecular probes for investigating biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D with custom synthesis and scale-up services.

Basic Information

Product Name	3‐Hydroxy‐1',2'‐Dihydrospiro[Cyclobutane‐1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One
CAS No.	1860028-21-2
Molecular Formula	C11H12N2O2
Molecular Weight	204.23 g/mol
Synonyms	3-Hydroxy-1',2'-dihydrospiro[cyclobutane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one; 3-Hydroxyspiro[cyclobutane-1,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; 1860028-21-2; Spiro[cyclobutane-1,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one, 3-hydroxy-; 3-Hydroxy-1',2'-dihydro-1'H-spiro[cyclobutane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one
EINECS	Contact for details

Quality Control

Our 3‐Hydroxy‐1',2'‐Dihydrospiro[Cyclobutane‐1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical R&D. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We support compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.