Description

L-Proline, 4-Methoxy-1-Methyl-, trans- Hydrochloride is a high-purity, non-proteinogenic amino acid derivative, specifically a substituted proline hydrochloride salt. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is essential for research and production in pharmaceutical development, agrochemical research, and specialized peptide chemistry, where precise stereochemistry and functional group manipulation are required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially protease inhibitors and other targeted therapeutics.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and modify the biological activity and stability of peptide-based compounds.
• Agrochemical Research: Serves as a building block for developing novel, chiral active ingredients with specific modes of action.
• Asymmetric Catalysis: Potential use as a precursor for chiral ligands or organocatalysts in stereoselective synthesis.
• Biochemical Research: Employed in studies of enzyme-substrate interactions and metabolic pathway analysis due to its modified proline structure.
• Material Science: Exploration in the synthesis of functionalized polymers and smart materials with specific chiral properties.

Basic Information

Product Name	L-Proline, 4-Methoxy-1-Methyl-, trans- Hydrochloride
CAS No.	1860012-51-6
Molecular Formula	C7H14ClNO3 • (Contact for details on solvate, if any)
Molecular Weight	Contact for details
Synonyms	(2S,4R)-4-Methoxy-1-methylpyrrolidine-2-carboxylic acid hydrochloride; trans-4-Methoxy-1-methyl-L-proline hydrochloride; 4-Methoxy-1-methyl-L-proline HCl; 1-Methyl-4-methoxy-L-proline hydrochloride; L-1-Methyl-4-methoxypyrrolidine-2-carboxylic acid hydrochloride; (4R)-4-Methoxy-1-methyl-L-proline hydrochloride; (2S,4R)-1-Methyl-4-methoxypyrrolidine-2-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Methoxy-1-Methyl-, trans- Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from chiral HPLC, NMR, and other relevant spectroscopic and chromatographic methods to confirm the specified grade and meet your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.