Description

D-Proline, 4-Methoxy-1-Methyl-, (4S)- Hydrochloride is a high-purity, non-proteinogenic amino acid derivative used as a critical chiral building block in advanced organic synthesis. This compound is valued for its defined stereochemistry and functional group, which are essential for constructing complex molecules with high enantiomeric purity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and asymmetric catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Peptidomimetics Research: Used to introduce constrained proline analogs into peptide chains to study structure-activity relationships and improve metabolic stability.
• Chemical Biology Probes: Incorporated into molecular probes for studying biological processes and protein interactions.
• Agrochemical Research: Serves as a building block in the synthesis of novel chiral compounds for crop protection agents.
• Academic & Industrial R&D: Utilized in fundamental organic chemistry research and process development for scale-up synthesis.

Basic Information

Product Name	D-Proline, 4-Methoxy-1-Methyl-, (4S)- Hydrochloride
CAS No.	1860012-49-2
Molecular Formula	C7H14ClNO3
Molecular Weight	195.64 g/mol
Synonyms	(4S)-4-Methoxy-1-methyl-D-proline hydrochloride; (2S,4S)-4-Methoxy-1-methylpyrrolidine-2-carboxylic acid hydrochloride; 1-Methyl-4-methoxy-D-proline HCl; D-1-Methyl-4-methoxyproline hydrochloride; (4S)-1-Methyl-4-methoxy-D-proline hydrochloride; 4-Methoxy-1-methyl-L-proline hydrochloride (enantiomer); 4-Methoxy-N-methyl-D-proline hydrochloride
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Methoxy-1-Methyl-, (4S)- Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.