Description

1-{(1S,2R)-1-[(11Br)-8,9,10,11,12,13,14,15-Octahydrodinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yloxy]-1-Phenylpropan-2-Yl}-3-Phenylurea, Min. 97% is a high-purity, stereochemically defined organophosphorus compound. This advanced chiral intermediate is critical for the synthesis of complex molecules, offering precise control over stereochemistry in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other targeted therapeutic programs.
• Agrochemical Research: Used in the development of advanced, stereoselective pesticides and herbicides where specific spatial configuration is essential for biological activity.
• Catalyst Ligand Precursor: Serves as a sophisticated precursor for chiral ligands in asymmetric catalysis, enabling highly enantioselective transformations.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study enzyme mechanisms and biological pathways.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant scale, ensuring stereochemical integrity is maintained.
• Academic Research: A valuable compound for universities and research institutes exploring new methodologies in organic and organometallic chemistry.

Basic Information

Product Name	1-{(1S,2R)-1-[(11Br)-8,9,10,11,12,13,14,15-Octahydrodinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yloxy]-1-Phenylpropan-2-Yl}-3-Phenylurea
CAS No.	1858224-21-1
Molecular Formula	C36H35BrNO4P
Molecular Weight	656.55 g/mol
Synonyms	(1S,2R)-1-[(11Br)-8,9,10,11,12,13,14,15-Octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yloxy]-1-phenylpropan-2-yl 3-phenylurea; 1-[(1S,2R)-1-[(11Br)-8,9,10,11,12,13,14,15-Octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]oxy-1-phenylpropan-2-yl]-3-phenylurea; Bromo-Dinaphthodioxaphosphepin Urea Derivative; Chiral Phosphite-Urea Hybrid Ligand Intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced under strict quality control protocols to ensure identity, purity, and stereochemical integrity. Our standard specification guarantees a minimum purity of 97%, typically determined by HPLC analysis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, chiral purity, and impurity profiles. We support development and cGMP requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Chiral Purity (Chiral HPLC)	Min. 98.0% de
Loss on Drying	Max. 1.0%
Residue on Ignition	Max. 0.1%
Single Unknown Impurity (HPLC)	Max. 0.5%
Total Impurities (HPLC)	Max. 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.