Description

4-Methyl-3-(trifluoromethyl)aniline hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl-substituted aniline structure. This compound is essential for the synthesis of complex active pharmaceutical ingredients (APIs), where the trifluoromethyl group is a critical pharmacophore known to enhance metabolic stability and bioavailability. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the bioactivity of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and advanced polymers.
• Chemical Research & Development: A versatile reagent for organic synthesis, enabling the introduction of the aniline moiety in complex molecular architectures.

Basic Information

Product Name	4-Methyl-3-(trifluoromethyl)aniline hydrochloride
CAS No.	1845696-01-6
Molecular Formula	C8H9ClF3N
Molecular Weight	211.61 g/mol
Synonyms	3-(Trifluoromethyl)-p-toluidine hydrochloride; 4-Methyl-3-(trifluoromethyl)benzenamine hydrochloride; 3-Amino-4-methylbenzotrifluoride hydrochloride; 3-Trifluoromethyl-4-methylaniline hydrochloride; 4-Methyl-α,α,α-trifluoro-m-toluidine hydrochloride; 3-(Trifluoromethyl)-4-methylaniline hydrochloride; Benzenamine, 4-methyl-3-(trifluoromethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-(trifluoromethyl)aniline hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.