Description

T-Boc-Aminooxy-Peg1-Amine CAS NO 1844894-82-1 is a bifunctional polyethylene glycol (PEG) linker featuring orthogonal amine and aminooxy protecting groups. This compound is essential for creating stable, site-specific bioconjugates and for the controlled synthesis of complex molecules in drug discovery and materials science. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotech, and diagnostic industries for applications such as antibody-drug conjugate (ADC) development, peptide modification, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key building block for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Peptide and Protein Modification: Enables site-specific conjugation via oxime ligation with carbonyl groups (e.g., ketones, aldehydes) on biomolecules.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and chromatography resins with amine-reactive groups for further coupling.
• Polymer and Dendrimer Synthesis: Acts as a versatile monomer or branching unit for creating functionalized PEG-based polymers with controlled architectures.
• Small Molecule Prodrug Development: Facilitates the attachment of amine-containing drug molecules for creating targeted prodrugs with improved solubility.
• Crosslinking Agent: Employed in the preparation of hydrogels and biomaterials requiring specific, stable covalent bonds.

Basic Information

Product Name	T-Boc-Aminooxy-Peg1-Amine
CAS No.	1844894-82-1
Molecular Formula	C11H24N2O5
Molecular Weight	264.32 g/mol
Synonyms	1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid, 15-[(1,1-Dimethylethoxy)amino]-14-oxo-; 2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl (tert-butoxy)carbamate; Boc-NH-PEG1-ONH2; tert-Butyl N-(17-amino-3,6,9,12,15-pentaoxaheptadec-16-yl)carbamate; Amino-PEG4-t-butyloxycarbonylaminooxy; Boc-Aminooxy-PEG4-amine; 15-((tert-Butoxycarbonyl)amino)-14-oxo-3,6,9,12-tetraoxapentadecan-1-amine
EINECS	Contact for details

Quality Control

Every batch of T-Boc-Aminooxy-Peg1-Amine is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.