Description

m-Peg3-Onhboc is a specialized bifunctional polyethylene glycol (PEG) derivative featuring a Boc-protected hydroxylamine group. This compound is a critical building block in the synthesis of complex molecules, enabling precise conjugation and linker chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing antibody-drug conjugates (ADCs), peptide modifications, and advanced drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide and Protein Modification: Used to introduce PEG spacers and functional handles onto peptides or proteins to enhance solubility, stability, and pharmacokinetic properties.
• Prodrug Development: Facilitates the creation of prodrugs where the active pharmaceutical ingredient is released upon specific biological triggers.
• Bioconjugation Reagent: Acts as a versatile tool for crosslinking biomolecules, such as enzymes, antibodies, or oligonucleotides, with other entities for diagnostic or therapeutic applications.
• Polymer Chemistry: Employed as a monomer or functional initiator in the synthesis of tailored, functionalized PEG-based polymers and hydrogels.
• Chemical Biology Probes: Integral for synthesizing probes used in target identification, cellular imaging, and mechanism-of-action studies.

Basic Information

Product Name	m-Peg3-Onhboc
CAS No.	1835759-87-9
Molecular Formula	C17H35NO7
Molecular Weight	365.47 g/mol
Synonyms	1-Amino-3,6,9-trioxa-12-azatetradecan-14-oic acid, 13-(1,1-dimethylethyl) 14-(4-nitrophenyl) ester; 3,6,9-Trioxa-12-azatetradecan-1-amine, 14-[[(1,1-dimethylethoxy)carbonyl]amino]-13-oxo-, 4-nitrophenyl ester; Boc-NH-PEG3-ONp; Boc-Amino-PEG3-acid ONp ester; tert-Butyl (14-oxo-13-((4-nitrophenoxy)carbonyl)-3,6,9-trioxa-12-azatetradecyl)carbamate; 4-Nitrophenyl (Boc-amino-PEG3)acetate
EINECS	Contact for details

Quality Control

Our m-Peg3-Onhboc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your research and cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.