Description

2,2'-Bi-1H-Imidazole, 4,4',5,5'-Tetrahydro-4,4'-Bis(1-Methylethyl)-1,1'-Bis(4-Methylphenyl)-, (4S,4'S)- is a high-purity, chiral organic compound belonging to the class of substituted biimidazoles. This compound is valued for its role as a sophisticated ligand precursor or chiral building block in advanced chemical synthesis. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and catalysts. The specific stereochemistry (4S,4'S) makes it essential for applications requiring precise molecular recognition and enantioselective transformations.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Catalyst Ligand Synthesis: Used to prepare specialized N-heterocyclic carbene (NHC) or other bidentate ligands for transition metal catalysis in asymmetric synthesis.
• Agrochemical Research: Acts as a building block for developing new-generation pesticides and herbicides with improved selectivity and environmental profiles.
• Material Science: Investigated for the development of chiral organic frameworks (COFs), polymers, or liquid crystals with specific optical properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development in organic and organometallic chemistry.

Basic Information

Product Name	2,2'-Bi-1H-Imidazole, 4,4',5,5'-Tetrahydro-4,4'-Bis(1-Methylethyl)-1,1'-Bis(4-Methylphenyl)-, (4S,4'S)-
CAS No.	1827669-26-0
Molecular Formula	C26H32N4
Molecular Weight	400.56 g/mol
Synonyms	(4S,4'S)-4,4',5,5'-Tetrahydro-4,4'-bis(1-methylethyl)-1,1'-bis(4-methylphenyl)-2,2'-bi-1H-imidazole; (S,S)-H8-BIMIP; Chiral Biimidazole Derivative; 1,1'-Bis(4-methylphenyl)-4,4',5,5'-tetrahydro-4,4'-diisopropyl-2,2'-biimidazole (S,S)-isomer; Ligand Precursor 1827669-26-0; (4S,4'S)-H8-BIMIP; Tetrahydrobiimidazole ligand.
EINECS	Contact for details

Quality Control

Every batch of our 2,2'-Bi-1H-Imidazole derivative is produced under controlled conditions and undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity. Our quality protocols are designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, enantiomeric excess, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.