Description

4-Iodo-1H-Imidazole-2-Carboxylic Acid is a high-value iodinated heterocyclic building block, specifically functionalized for advanced synthetic applications. This compound is critical for medicinal chemistry research and development, offering a versatile handle for cross-coupling reactions and molecular diversification. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel drug candidates, particularly in the areas of enzyme inhibitors and targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in oncology and antiviral research.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and enzyme functions.
• Agrochemical Research: A potential intermediate in the discovery of new herbicides and fungicides with novel modes of action.

Basic Information

Product Name	4-Iodo-1H-Imidazole-2-Carboxylic Acid
CAS No.	1824286-45-4
Molecular Formula	C4H3IN2O2
Molecular Weight	237.98 g/mol
Synonyms	4-Iodo-1H-imidazole-2-carboxylic acid; 2-Carboxy-4-iodoimidazole; 4-Iodo-2-imidazolecarboxylic Acid; 4-Iodo-1H-imidazole-2-carboxylic acid (CAS 1824286-45-4); 1H-Imidazole-2-carboxylic acid, 4-iodo-; 4-Iodoimidazole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Iodo-1H-Imidazole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.