Description

tert-Butyl 3-(Hydroxymethyl)-2,8-Diazaspiro[4.5]Decane-8-Carboxylate (Wx101471) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic diaza scaffold. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the synthesis of linker components or warhead ligands for targeted protein degradation platforms.
• CNS Drug Discovery: Employed in the research and synthesis of potential therapeutics for neurological and psychiatric disorders.
• Oncology Research: Utilized as a building block for potential kinase inhibitors or other oncology-targeted small molecules.
• Chemical Biology Probes: Acts as a starting material for creating tool compounds to study specific biological pathways and protein functions.

Basic Information

Product Name	tert-Butyl 3-(Hydroxymethyl)-2,8-Diazaspiro[4.5]Decane-8-Carboxylate (Wx101471)
CAS No.	1824204-91-2
Molecular Formula	C14H26N2O3
Molecular Weight	270.37 g/mol
Synonyms	8-Boc-3-(hydroxymethyl)-2,8-diazaspiro[4.5]decane; tert-Butyl 3-(hydroxymethyl)-2,8-diazaspiro[4.5]decane-8-carboxylate; 2,8-Diazaspiro[4.5]decane-8-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester; WX-101471; Wx101471; 3-(Hydroxymethyl)-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 8-(tert-Butoxycarbonyl)-3-(hydroxymethyl)-2,8-diazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Hydroxymethyl)-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.