Description

7-Ethynyl-2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure incorporating an ethynyl functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates for targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its reactive ethynyl moiety.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional degraders.
• Kinase Inhibitor Synthesis: Employed in the construction of heterocyclic cores for potential kinase inhibitors.
• Chemical Biology Probes: Utilized in the development of activity-based probes for studying enzyme function and target engagement.
• Academic & Contract Research: Supplied to universities and CROs for exploratory research in organic and bioorganic chemistry.

Basic Information

Product Name	7-Ethynyl-2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One
CAS No.	1824123-04-7
Molecular Formula	C9H6N2O2
Molecular Weight	174.16 g/mol
Synonyms	7-Ethynyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-one; 7-Ethynyl-4H-pyrido[3,2-b][1,4]oxazin-3(2H)-one; 1824123-04-7; 7-Ethynyl-2H-[1,4]oxazino[2,3-b]pyridin-3(4H)-one; 7-Ethynyl-3,4-dihydro-2H-pyrido[3,2-b]-1,4-oxazin-3-one
EINECS	Contact for details

Quality Control

Our 7-Ethynyl-2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.