Description

4-(Bicyclo[1.1.1]pentan-1-yl)phenol is a specialized phenolic compound featuring a rigid bicyclo[1.1.1]pentane bridgehead substituent. This unique structural motif is of significant interest in modern medicinal chemistry and materials science for its role as a bioisostere, offering improved physicochemical properties. It serves as a key synthetic intermediate for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and advanced functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing drug candidates, particularly where the bicyclo[1.1.1]pentane unit is used to replace a *para*-substituted benzene ring to enhance metabolic stability, solubility, and reduce planarity.
• Agrochemical Research: Used in the development of new generation herbicides, fungicides, and pesticides with potentially improved efficacy and environmental profiles.
• Polymer & Material Science: Serves as a monomer or functional additive for creating high-performance polymers, liquid crystals, and advanced resins with tailored thermal and mechanical properties.
• Ligand & Catalyst Development: Employed in the synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design of molecular probes and tools for studying biological systems and protein-ligand interactions.

Basic Information

Product Name	4-(Bicyclo[1.1.1]pentan-1-yl)phenol
CAS No.	1823939-03-2
Molecular Formula	C11H12O
Molecular Weight	160.21 g/mol
Synonyms	4-(Bicyclo[1.1.1]pentan-1-yl)phenol; 4-(1-Bicyclo[1.1.1]pentanyl)phenol; Phenol, 4-(bicyclo[1.1.1]pentan-1-yl)-; 1-(4-Hydroxyphenyl)bicyclo[1.1.1]pentane; BCP-phenol; [1.1.1]Propellane, 1-(4-hydroxyphenyl)- (derivative)
EINECS	Contact for details

Quality Control

Our 4-(Bicyclo[1.1.1]pentan-1-yl)phenol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from techniques such as HPLC, GC, NMR, and mass spectrometry. Specifications can be tailored to meet the requirements of cGMP and other relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.