Description

2-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-8-Thia-2-Azaspiro[4.5]Decane-4-Carboxylic Acid 8,8-Dioxide is a sophisticated, high-purity chemical building block designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise molecular architecture in complex organic synthesis. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in developing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing spirocyclic and heterocyclic scaffolds.
• Peptidomimetics Research: Used in the design and construction of peptide analogs and mimetics due to its Fmoc-protected carboxylic acid and constrained ring system.
• Protease Inhibitor Development: Serves as a core structure or precursor for molecules targeting protease enzymes, leveraging the sulfone and carboxylic acid functionalities.
• Chemical Biology Probes: Employed in the creation of specialized probes and tools for studying enzyme function and biological pathways.
• Solid-Phase Peptide Synthesis (SPPS): Functions as a protected amino acid derivative for the controlled assembly of peptides on resin.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Product Name	2-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-8-Thia-2-Azaspiro[4.5]Decane-4-Carboxylic Acid 8,8-Dioxide
CAS No.	1823835-45-5
Molecular Formula	C27H27NO7S
Molecular Weight	509.57 g/mol
Synonyms	Fmoc-8-Thia-2-azaspiro[4.5]decane-4-carboxylic acid 8,8-dioxide; Fmoc-Thia-Azaspirodecane-CO2H dioxide; 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)-8-thia-2-azaspiro[4.5]decane-4-carboxylic acid 8,8-dioxide; 8-Thia-2-azaspiro[4.5]decane-4-carboxylic acid, 2-(((9H-fluoren-9-yl)methoxy)carbonyl)-, 8,8-dioxide; CAS 1823835-45-5; Fmoc-protected cyclic sulfone amino acid; Spirocyclic Fmoc-amino acid sulfone.
EINECS	Contact for details

Quality Control

Our 2-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-8-Thia-2-Azaspiro[4.5]Decane-4-Carboxylic Acid 8,8-Dioxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.