Description

tert-Butyl 2,3-Dioxo-2,3-Dihydrospiro[Indene-1,4-Piperidine]-1-Carboxylate (Wx106402) is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indene-piperidine scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly for central nervous system (CNS) and other targeted therapies. The product, with CAS number 1823835-30-8, is supplied under stringent quality control to ensure batch-to-batch consistency for critical research and development applications.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structure makes it a candidate for incorporation into bifunctional molecules designed for targeted protein degradation.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological processes and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for clinical trials.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 2,3-Dioxo-2,3-Dihydrospiro[Indene-1,4-Piperidine]-1-Carboxylate (Wx106402)
CAS No.	1823835-30-8
Molecular Formula	C18H21NO4
Molecular Weight	315.36 g/mol
Synonyms	1-tert-Butyl 2,3-Dioxospiro[indene-1,4'-piperidine]-1'-carboxylate; tert-Butyl 2,3-dioxo-1,2,3,4-tetrahydrospiro[indene-1,4'-piperidine]-1'-carboxylate; Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 2,3-dihydro-2,3-dioxo-, 1,1-dimethylethyl ester; WX-106402; Wx106402; Boc-protected spirocyclic diketone intermediate; 1-Boc-2,3-dioxospiro[indene-1,4-piperidine]
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 2,3-Dioxo-2,3-Dihydrospiro[Indene-1,4-Piperidine]-1-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as identity, purity, and impurity profile. Our quality protocols are designed to support regulatory filings and ensure reliable supply for critical development timelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.