Description

2-(4-Bromo-2-Chlorophenyl)-2,2-Difluoroacetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its difluoroacetic acid moiety attached to a halogenated phenyl ring. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and antiviral drug discovery.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, especially those targeting kinase inhibition.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging its halogenated structure.
• Material Science: Serves as a precursor for specialty monomers and polymers with unique fluorinated properties.
• Organic Synthesis: Employed in cross-coupling reactions and as a building block for introducing the difluoroacetate group into complex molecules.
• Life Science Research: Used as a reference standard and biochemical tool in academic and industrial R&D laboratories.

Basic Information

Product Name	2-(4-Bromo-2-Chlorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1823816-46-1
Molecular Formula	C8H4BrClF2O2
Molecular Weight	285.47 g/mol
Synonyms	2-(4-Bromo-2-chlorophenyl)-2,2-difluoroacetic acid; α,α-Difluoro-4-bromo-2-chlorophenylacetic Acid; 4-Bromo-2-chloro-α,α-difluorophenylacetic Acid; 2,2-Difluoro-2-(4-bromo-2-chlorophenyl)acetic Acid; (4-Bromo-2-chlorophenyl)difluoroacetic Acid; Difluoro(4-bromo-2-chlorophenyl)acetic Acid; CAS 1823816-46-1
EINECS	Contact for details

Quality Control

Our 2-(4-Bromo-2-Chlorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.