Description

6-Benzyl-2,6-Diaza-Spiro[3.4]Octane-2,8-Dicarboxylic Acid 2-tert-Butyl Ester is a sophisticated spirocyclic building block of significant interest in modern organic synthesis. This compound is valued for its rigid, three-dimensional scaffold, which is crucial for developing novel molecules with enhanced biological activity and specific binding properties. It is primarily sought after by research chemists and process development teams in the pharmaceutical and agrochemical industries for use in drug discovery programs and the synthesis of complex active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Drug Discovery Scaffold: Utilized in fragment-based drug design and combinatorial chemistry libraries due to its spirocyclic structure, which improves molecular complexity and can enhance pharmacokinetic properties.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides, where its unique geometry can lead to novel modes of action.
• Chemical Biology Probe Development: Used to create molecular probes for studying enzyme function and protein-protein interactions within biological systems.
• Ligand Synthesis for Catalysis: Potential use in constructing novel chiral ligands for asymmetric catalysis, leveraging the nitrogen atoms within the diaza-spiro structure.

Basic Information

Product Name	6-Benzyl-2,6-Diaza-Spiro[3.4]Octane-2,8-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	1823807-74-4
Molecular Formula	C20H28N2O4
Molecular Weight	360.45 g/mol
Synonyms	2-tert-Butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2,8-dicarboxylate; 2,6-Diaza-spiro[3.4]octane-2,8-dicarboxylic acid, 6-benzyl-, 2-(1,1-dimethylethyl) ester; 6-Benzyl-2,6-diaza-spiro[3.4]octane-2,8-dicarboxylic acid 2-tert-butyl ester; tert-Butyl 6-benzyl-2,8-dioxo-2,6-diazaspiro[3.4]octane-2-carboxylate; BOC-Protected 6-Benzyl-2,6-diazaspiro[3.4]octane-8-carboxylic acid derivative; Spirocyclic Diaza Building Block 1823807-74-4.
EINECS	Contact for details

Quality Control

Our production of 6-Benzyl-2,6-Diaza-Spiro[3.4]Octane-2,8-Dicarboxylic Acid 2-tert-Butyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation, to ensure consistency and reliability for critical research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.