Description

8-Benzyl 1-tert-Butyl 2-(Aminomethyl)-1,8-Diazaspiro[4.5]Decane-1,8-Dicarboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and protected amine structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with potential applications in central nervous system (CNS) and other therapeutic areas. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Spirocyclic Compound Library Synthesis: A valuable scaffold for creating diverse chemical libraries for high-throughput screening in drug discovery.
• Peptidomimetic Development: The protected aminomethyl and diazaspiro[4.5]decane core is useful in designing peptide mimics with enhanced metabolic stability.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	8-Benzyl 1-tert-Butyl 2-(Aminomethyl)-1,8-Diazaspiro[4.5]Decane-1,8-Dicarboxylate
CAS No.	1823776-49-3
Molecular Formula	C22H33N3O4
Molecular Weight	403.52 g/mol
Synonyms	1,8-Diazaspiro[4.5]decane-1,8-dicarboxylic acid, 2-(aminomethyl)-, 1-(1,1-dimethylethyl) 8-(phenylmethyl) ester; tert-Butyl 2-(aminomethyl)-8-(benzyloxycarbonyl)-1,8-diazaspiro[4.5]decane-1-carboxylate; 2-(Aminomethyl)-1,8-diazaspiro[4.5]decane-1,8-dicarboxylate, 1-tert-butyl 8-benzyl ester; 1-N-Boc-8-N-Cbz-2-(aminomethyl)-1,8-diazaspiro[4.5]decane; Boc-Cbz Protected Aminomethyl Diazaspiro[4.5]decane; CAS 1823776-49-3
EINECS	Contact for details

Quality Control

Our 8-Benzyl 1-tert-Butyl 2-(Aminomethyl)-1,8-Diazaspiro[4.5]Decane-1,8-Dicarboxylate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We can support development projects requiring compliance with ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.