Description

5-Fluoroazepan-4-Ol Hydrochloride (Wx601137) is a high-purity, advanced pharmaceutical intermediate characterized by its specific fluorine-substituted azepane structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) drugs, enzyme inhibitors, and other bioactive molecules targeting G-protein-coupled receptors (GPCRs).

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new chemical entities (NCEs), particularly for CNS-targeting drugs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• GPCR Ligand Synthesis: Serves as a core structure for creating potent and selective ligands for various G-protein-coupled receptors.
• Protease & Enzyme Inhibitor Development: Employed in the synthesis of potential inhibitors for proteolytic enzymes and other biological targets.
• Preclinical & Process Chemistry: Utilized in scaling up synthetic routes from milligram to kilogram scale for preclinical and early-phase clinical trials.
• Academic Research: Used in university and institutional labs for studying fluorinated heterocycle chemistry and its biological implications.

Basic Information

Item	Details
Product Name	5-Fluoroazepan-4-Ol Hydrochloride (Wx601137)
CAS No.	1823331-71-0
Molecular Formula	C6H13FNO•HCl
Molecular Weight	169.63 g/mol (Free base)
Synonyms	5-Fluoro-4-hydroxyazepane hydrochloride; 4-Hydroxy-5-fluoroazepane HCl; 5-Fluoroazepan-4-ol HCl; Azepan-4-ol, 5-fluoro-, hydrochloride; WX-601137; Wx601137
EINECS	Contact for details

Quality Control

Our 5-Fluoroazepan-4-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure full traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.