Description

tert-Butyl 7-Hydroxy-1-Azaspiro[4.4]Nonane-1-Carboxylate CAS NO 1823268-34-3 is a high-purity, protected amino alcohol derivative featuring a unique spirocyclic structure. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile chiral building block for complex organic synthesis. It is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for constructing novel drug candidates targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric drug discovery.
• Chiral Building Block: Utilized in asymmetric synthesis to introduce stereochemical complexity into target molecules.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies due to its constrained spirocyclic scaffold.
• Peptidomimetic Synthesis: Used to create conformationally restricted peptide analogs for enhanced metabolic stability and receptor selectivity.
• Chemical Biology Probes: Acts as a scaffold for developing tool compounds to study biological pathways and protein function.
• Fine Chemical Production: Serves as a starting material for the manufacture of specialty chemicals with high added value.

Basic Information

Product Name	tert-Butyl 7-Hydroxy-1-Azaspiro[4.4]Nonane-1-Carboxylate
CAS No.	1823268-34-3
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	1-Boc-7-Hydroxy-1-azaspiro[4.4]nonane; 7-Hydroxy-1-azaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester; tert-Butyl 7-hydroxy-1-azaspiro[4.4]nonane-1-carboxylate; 1-Azaspiro[4.4]nonane-1-carboxylic acid, 7-hydroxy-, 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-7-hydroxy-1-azaspiro[4.4]nonane; Boc-7-Hydroxy-1-azaspiro[4.4]nonane; 1823268-34-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Hydroxy-1-Azaspiro[4.4]Nonane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.