Description

2-tert-Butyl 8-Methyl 5-Thia-2-Azaspiro[3.4]Octane-2,8-Dicarboxylate is a high-value spirocyclic building block and advanced pharmaceutical intermediate. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting complex diseases. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its unique constrained spiro scaffold into new chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug discovery programs.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new chemical space due to its three-dimensional, spirocyclic structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or core component in the design of bifunctional molecules for targeted protein degradation.
• Agrochemical Synthesis: Intermediate in the research and development of new generation herbicides and fungicides with novel modes of action.
• Ligand & Catalyst Development: Precursor for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Used to develop tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	2-tert-Butyl 8-Methyl 5-Thia-2-Azaspiro[3.4]Octane-2,8-Dicarboxylate
CAS No.	1823264-51-2
Molecular Formula	C14H23NO4S
Molecular Weight	301.40 g/mol
Synonyms	tert-Butyl 8-methyl 5-thia-2-azaspiro[3.4]octane-2,8-dicarboxylate; 5-Thia-2-azaspiro[3.4]octane-2,8-dicarboxylic acid, 2-(1,1-dimethylethyl) 8-methyl ester; 2-(tert-Butoxycarbonyl)-8-(methoxycarbonyl)-5-thia-2-azaspiro[3.4]octane; Spiro[3.4]octane-2,8-dicarboxylate derivative; BOC-protected thia-azaspiro compound; CAS 1823264-51-2
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl 8-Methyl 5-Thia-2-Azaspiro[3.4]Octane-2,8-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.