Description

tert-Butyl 7-Benzyl-9-(Hydroxymethyl)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and diazepane structure. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily needed by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in the discovery of new therapeutic agents, particularly in central nervous system (CNS) and oncology drug pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries via parallel synthesis to explore structure-activity relationships (SAR).
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized in the development of selective molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 7-Benzyl-9-(Hydroxymethyl)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate
CAS No.	1823258-46-3
Molecular Formula	C20H30N2O3
Molecular Weight	346.47 g/mol
Synonyms	2,7-Diazaspiro[4.4]nonane-2-carboxylic acid, 7-benzyl-9-(hydroxymethyl)-, 1,1-dimethylethyl ester; tert-Butyl 7-benzyl-9-(hydroxymethyl)-2,7-diazaspiro[4.4]nonane-2-carboxylate; 7-Benzyl-9-(hydroxymethyl)-2,7-diazaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester; BOC-protected diazaspiro intermediate; 1823258-46-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Benzyl-9-(Hydroxymethyl)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with ICH guidelines and supports development from preclinical stages through to GMP manufacturing for clinical trials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.