Description

5-Fluoro-4-(Trifluoromethyl)Azepan-4-Ol Hydrochloride (Wx601543) is a high-purity, fluorinated azepane derivative hydrochloride salt, serving as a critical advanced pharmaceutical intermediate. This compound is valued for its unique molecular scaffold, which is essential for modulating the pharmacokinetic and physicochemical properties of novel drug candidates. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of complex bioactive molecules.

Application

• Key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Advanced intermediate for the synthesis of fluorinated analogs in medicinal chemistry programs, leveraging the fluorine atom for improved metabolic stability and bioavailability.
• Precursor in the development of novel agrochemicals, where the trifluoromethyl group can enhance biological activity and environmental persistence.
• Versatile scaffold for constructing complex heterocyclic libraries used in high-throughput screening for drug discovery.
• Used in academic and industrial research focused on exploring new chemical space within seven-membered nitrogen-containing rings.

Basic Information

Product Name	5-Fluoro-4-(Trifluoromethyl)Azepan-4-Ol Hydrochloride (Wx601543)
CAS No.	1823245-41-5
Molecular Formula	C8H12F4NO•HCl
Molecular Weight	249.64 g/mol (Free base)
Synonyms	4-(Trifluoromethyl)-5-fluoroazepan-4-ol hydrochloride; 5-Fluoro-4-(trifluoromethyl)azepan-4-ol HCl; 4-Azepanol, 5-fluoro-4-(trifluoromethyl)-, hydrochloride; WX-601543; Wx601543; 1823245-41-5; 4-Hydroxy-5-fluoro-4-(trifluoromethyl)azepane hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4-(Trifluoromethyl)Azepan-4-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent decomposition. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.