Description

(S)-2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethanamine Hcl is a high-purity chiral amine building block featuring a trifluoroethyl group and a tetrahydropyran ring. This compound is critical for introducing specific stereochemistry and fluorine atoms into advanced molecular architectures, enhancing metabolic stability and binding affinity. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including potential protease inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in antiviral and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides where the fluorine moiety and specific stereochemistry are crucial for bioactivity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Peptidomimetics Research: Incorporated into peptide backbones to create stable analogs resistant to enzymatic degradation for therapeutic and diagnostic applications.
• Material Science: Potential monomer or additive for specialty polymers where fluorine content can impart unique surface properties and chemical resistance.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme function and receptor interactions within biological systems.

Basic Information

Item	Details
Product Name	(S)-2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethanamine Hcl
CAS No.	1821813-96-0
Molecular Formula	C7H13ClF3NO
Molecular Weight	219.63 g/mol
Synonyms	(S)-2,2,2-Trifluoro-1-(Tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride; (S)-1-(Oxan-4-yl)-2,2,2-trifluoroethanamine hydrochloride; (S)-α-(Trifluoromethyl)-4-piperidinemethanol hydrochloride (related); (S)-4-(1-Amino-2,2,2-trifluoroethyl)tetrahydro-2H-pyran hydrochloride; (S)-Tetrahydropyran-4-yl(trifluoromethyl)methylamine HCl; TFAP-HCl (abbrev.); Chiral Trifluoroethyl Tetrahydropyranylamine HCl
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethanamine Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess, NMR, and mass spectrometry for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing purity, assay, and specific tests are provided and available upon request to ensure compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.