Description

(2S,4S)-1-(tert-Butoxycarbonyl)-4-(4-(3-Methyl-1-Phenyl-1H-Pyrazol-5-Yl)Piperazin-1-Yl)Pyrrolidine-2-Carboxylic Acid is a sophisticated chiral building block and advanced pharmaceutical intermediate of significant interest in modern drug discovery. Its value lies in its complex molecular architecture, which incorporates a protected pyrrolidine core linked to a substituted piperazine and a phenylpyrazole moiety, making it a key precursor for synthesizing targeted bioactive molecules. This compound is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutics, particularly in areas like kinase inhibition and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a building block for constructing compound libraries to explore structure-activity relationships (SAR) in drug discovery programs.
• Kinase Inhibitor Development: The structural features suggest potential utility in the design and synthesis of targeted kinase inhibitors.
• Peptidomimetic Synthesis: The pyrrolidine carboxylic acid core makes it valuable for creating peptidomimetics and conformationally constrained analogs.
• Chemical Biology Probes: Can be utilized to develop chemical probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A key material for fine chemical suppliers offering custom synthesis services for the pharmaceutical industry.

Basic Information

Product Name	(2S,4S)-1-(tert-Butoxycarbonyl)-4-(4-(3-Methyl-1-Phenyl-1H-Pyrazol-5-Yl)Piperazin-1-Yl)Pyrrolidine-2-Carboxylic Acid
CAS No.	1821705-03-6
Molecular Formula	C24H33N5O4
Molecular Weight	455.55 g/mol
Synonyms	1-Boc-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-L-proline; (2S,4S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidine-2-carboxylic acid; 1-N-Boc-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)-L-proline; (2S,4S)-1-(tert-Butoxycarbonyl)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidine-2-carboxylic acid; BOC-L-Proline derivative with phenylpyrazolylpiperazine; 1821705-03-6; Advanced Pyrrolidine-Piperazine Intermediate
EINECS	Contact for details

Quality Control

Our (2S,4S)-1-(tert-Butoxycarbonyl)-4-(4-(3-Methyl-1-Phenyl-1H-Pyrazol-5-Yl)Piperazin-1-Yl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.