Description

Methyl (1R,3S)-3-Aminocyclohexane-1-Carboxylate Hydrochloride is a high-purity chiral building block essential for the synthesis of complex pharmaceutical molecules. Its defined stereochemistry and protected amine functionality make it a valuable intermediate for creating active pharmaceutical ingredients (APIs) with specific biological activity. This compound is primarily targeted at research and development organizations and production facilities within the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder drug candidates.
• Peptidomimetic Chemistry: Used to introduce constrained cyclohexane-based amino acid analogs into peptide chains to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to construct complex molecular architectures.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.

Basic Information

Product Name	Methyl (1R,3S)-3-Aminocyclohexane-1-Carboxylate Hydrochloride
CAS No.	1821656-07-8
Molecular Formula	C8H16ClNO2
Molecular Weight	193.67 g/mol
Synonyms	(1R,3S)-Methyl 3-aminocyclohexanecarboxylate hydrochloride; (1R,3S)-3-Amino-1-cyclohexanecarboxylic acid methyl ester hydrochloride; Methyl trans-3-aminocyclohexanecarboxylate hydrochloride (relative stereochemistry); (1R,3S)-3-Aminocyclohexane-1-carboxylic acid methyl ester HCl; trans-Methyl 3-aminocyclohexanecarboxylate hydrochloride; (1R,3S)-Aminocyclohexanecarboxylic acid methyl ester hydrochloride; Methyl 3-amino-trans-cyclohexanecarboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (1R,3S)-3-Aminocyclohexane-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.