Description

(3S)-3-Amino-2,3-Dihydro-1H-Inden-5-Ol Hydrochloride is a chiral, pharmaceutically relevant intermediate characterized by its fused indane ring structure. This compound matters as a high-purity building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular research. It is primarily needed by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical suppliers serving the global life sciences market.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures due to its defined (3S) configuration.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Reference Standard: Used as an analytical standard for quality control and method development in API manufacturing.
• Preclinical Development: Supplied in development quantities for pharmacokinetic and toxicology studies.

Basic Information

Product Name	(3S)-3-Amino-2,3-Dihydro-1H-Inden-5-Ol Hydrochloride
CAS No.	1821520-81-3
Molecular Formula	C9H12ClNO
Molecular Weight	185.65 g/mol
Synonyms	(3S)-3-Amino-5-hydroxyindane hydrochloride; 5-Hydroxy-(3S)-3-aminoindane HCl; (S)-3-Amino-5-hydroxyindane hydrochloride; 1H-Inden-5-ol, 3-amino-2,3-dihydro-, hydrochloride, (3S)-; (3S)-3-Aminoindan-5-ol hydrochloride; (S)-3-Amino-2,3-dihydro-1H-inden-5-ol hydrochloride
EINECS	Contact for details

Quality Control

Our (3S)-3-Amino-2,3-Dihydro-1H-Inden-5-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.