Description

2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-6-carboxylic acid is a high-purity, advanced pharmaceutical intermediate characterized by its fused quinazoline-dione core. This compound is of significant commercial importance as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting specific enzymatic pathways. It is primarily required by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates and investigational new chemical entities.
• API Synthesis: Serves as a core scaffold for the development of potential kinase inhibitors and other enzyme-targeting therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Biochemical Reagent: May be utilized as a standard or reference compound in analytical and bioassay development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-6-carboxylic Acid
CAS No.	1821028-80-1
Molecular Formula	C10H6N2O4
Molecular Weight	218.17 g/mol
Synonyms	6-Carboxy-1,2,3,4-tetrahydro-2,4-quinazolinedione; Quinazoline-2,4(1H,3H)-dione-6-carboxylic acid; 1,2,3,4-Tetrahydro-2,4-dioxoquinazoline-6-carboxylic acid; 6-Carboxy-2,4-dihydroxyquinazoline; 2,4-Dihydroxyquinazoline-6-carboxylic acid; 6-Carboxy-2,4(1H,3H)-quinazolinedione; 2,4(1H,3H)-Quinazolinedione-6-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-6-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.