Description

1-Bromo-4-Methanesulfonyl-2-Nitro-5-(Trifluoromethoxy)Benzene is a high-value, multi-functionalized aromatic building block designed for advanced synthetic chemistry. Its unique combination of bromo, nitro, methanesulfonyl, and trifluoromethoxy substituents makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy and nitro groups contribute to enhanced biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent for creating specialty polymers, liquid crystals, and organic electronic materials with specific optoelectronic properties.
• Cross-Coupling Reactions: The bromo substituent is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and sulfonyl groups facilitate nucleophilic substitution reactions, allowing for further functionalization of the benzene core.
• Fluorine Chemistry Building Block: The trifluoromethoxy group provides a metabolically stable and lipophilic moiety, making it valuable in medicinal chemistry for improving drug-like properties.

Basic Information

Product Name	1-Bromo-4-Methanesulfonyl-2-Nitro-5-(Trifluoromethoxy)Benzene
CAS No.	1820739-59-0
Molecular Formula	C8H5BrF3NO5S
Molecular Weight	364.10 g/mol
Synonyms	4-Bromo-2-nitro-1-(trifluoromethoxy)-5-(methylsulfonyl)benzene; 2-Nitro-4-bromo-1-(trifluoromethoxy)-5-(methylsulfonyl)benzene; 5-Bromo-2-nitro-4-(trifluoromethoxy)phenyl methyl sulfone; 1-Bromo-4-(methylsulfonyl)-2-nitro-5-(trifluoromethoxy)benzene; Benzene, 1-bromo-4-(methylsulfonyl)-2-nitro-5-(trifluoromethoxy)-; CAS 1820739-59-0
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Methanesulfonyl-2-Nitro-5-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound may be moisture-sensitive; ensure the container is kept tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.