Description

Benzene, 2-Bromo-1-(Methylsulfonyl)-4-(Trifluoromethyl)- is a high-value, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound is engineered to provide a trifluoromethyl group, a bromine atom, and a methylsulfonyl moiety on a single benzene ring, offering exceptional versatility for constructing complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl systems.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore the effects of sulfonyl and trifluoromethyl groups on potency and pharmacokinetics.
• Fluorine Chemistry Research: An important reagent for introducing fluorine-containing motifs into target molecules, a critical area in modern drug design.

Basic Information

Product Name	Benzene, 2-Bromo-1-(Methylsulfonyl)-4-(Trifluoromethyl)-
CAS No.	1820703-37-4
Molecular Formula	C9H6BrF3O2S
Molecular Weight	315.11 g/mol
Synonyms	2-Bromo-1-(methylsulfonyl)-4-(trifluoromethyl)benzene; 1-Bromo-2-(methylsulfonyl)-5-(trifluoromethyl)benzene; 2-Bromo-α,α,α-trifluoro-4-(methylsulfonyl)toluene; [2-Bromo-4-(trifluoromethyl)phenyl](methyl)sulfone; Methyl 2-bromo-4-(trifluoromethyl)phenyl sulfone
EINECS	Contact for details

Quality Control

Our Benzene, 2-Bromo-1-(Methylsulfonyl)-4-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation from atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.