Description

6-Bromo-7-(Trifluoromethyl)Quinoline is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is particularly significant for its unique molecular architecture, which combines a bromo-substituent for cross-coupling reactions with a trifluoromethyl group to impart desirable properties like enhanced metabolic stability and lipophilicity. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental profile.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig couplings to construct complex molecular architectures.
• Fluorine Chemistry: Acts as a valuable building block for introducing the CF3 moiety into target molecules, a common strategy in modern drug design.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological processes and target engagement.

Basic Information

Product Name	6-Bromo-7-(Trifluoromethyl)Quinoline
CAS No.	1820666-89-4
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	6-Bromo-7-(trifluoromethyl)quinoline; 7-(Trifluoromethyl)-6-bromoquinoline; Quinoline, 6-bromo-7-(trifluoromethyl)-; 6-Bromo-7-trifluoromethylquinoline; 1820666-89-4
EINECS	Contact for details

Quality Control

Our 6-Bromo-7-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.