Description

5-(Benzyloxycarbonyl)-5-Azaspiro[2.3]Hexane-1-Carboxylic Acid is a high-value, protected spirocyclic amino acid derivative serving as a critical building block in advanced organic synthesis. Its unique constrained spiro[2.3]hexane scaffold is prized for introducing three-dimensional complexity and modulating physicochemical properties in target molecules. This compound is essential for medicinal chemistry researchers and process development scientists in the pharmaceutical and biotechnology industries, particularly for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for constructing complex active pharmaceutical ingredients (APIs) and peptidomimetics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space and improve drug-like properties.
• Protease Inhibitor Development: The spirocyclic structure and carboxylic acid functionality make it a valuable precursor for designing inhibitors of various enzymes.
• Conformationally Constrained Peptide Synthesis: Incorporates rigid, three-dimensional geometry into peptide backbones to enhance metabolic stability and receptor selectivity.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds and probes to study biological pathways and protein function.
• Process Chemistry & Scale-up: Supplied in development and commercial quantities to support route scouting and cGMP manufacturing campaigns.

Basic Information

Product Name	5-(Benzyloxycarbonyl)-5-Azaspiro[2.3]Hexane-1-Carboxylic Acid
CAS No.	1820619-57-5
Molecular Formula	C15H17NO4
Molecular Weight	275.30 g/mol
Synonyms	5-[(Benzyloxy)carbonyl]-5-azaspiro[2.3]hexane-1-carboxylic acid; 1-Carboxy-5-(benzyloxycarbonyl)-5-azaspiro[2.3]hexane; 5-Azaspiro[2.3]hexane-1-carboxylic acid, 5-[(phenylmethoxy)carbonyl]-; Cbz-Protected 5-Azaspiro[2.3]hexane-1-carboxylic Acid; (1S,5R)-5-[(Benzyloxy)carbonyl]-5-azaspiro[2.3]hexane-1-carboxylic acid (for chiral form); Z-5-Azaspiro[2.3]hexane-1-COOH; CAS 1820619-57-5
EINECS	Contact for details

Quality Control

Our 5-(Benzyloxycarbonyl)-5-Azaspiro[2.3]Hexane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and comprehensive identification, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for chiral grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.