Description

8-Iodo-1H-Benzo[D][1,3]Oxazin-2(4H)-One is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring both an iodine substituent and a fused oxazinone ring, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, particularly in lead optimization and scaffold diversification.
• Medicinal Chemistry: Used for structure-activity relationship (SAR) studies and in the synthesis of libraries for high-throughput screening.
• Agrochemical Research: Acts as a building block for developing new herbicides, fungicides, or insecticides with potentially novel modes of action.
• Chemical Biology: Employed as a probe or labeling agent in biochemical studies due to the reactivity of the iodine moiety.
• Material Science Precursor: Potential use in the synthesis of specialized organic electronic materials or ligands for catalysis.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form new carbon-carbon bonds.

Basic Information

Item	Details
Product Name	8-Iodo-1H-Benzo[D][1,3]Oxazin-2(4H)-One
CAS No.	1820612-81-4
Molecular Formula	C8H6INO2
Molecular Weight	275.05 g/mol
Synonyms	8-Iodo-1H-1,3-benzoxazin-2(4H)-one; 8-Iodo-3,4-dihydro-1H-benzo[d][1,3]oxazin-2-one; 8-Iodo-2H-3,4-dihydro-1,3-benzoxazin-2-one; 8-Iodo-3,4-dihydro-2H-1,3-benzoxazin-2-one; 1820612-81-4; 8-Iodo-dihydrobenzoxazinone
EINECS	Contact for details

Quality Control

Our 8-Iodo-1H-Benzo[D][1,3]Oxazin-2(4H)-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry for full structural confirmation. A Certificate of Analysis (COA) detailing all specifications is available with every shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.