Description

(1R,2S)-2-(Methoxymethyl)Cyclobutan-1-Amine Hydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly for complex small-molecule therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery, process chemistry, and the production of enantiomerically pure compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to introduce the cyclobutane scaffold with high stereoselectivity.
• Peptidomimetics & Bioisosteres: Incorporation into peptide backbones to create conformationally restricted analogs with improved metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for target identification and validation studies.
• Process Research & Development (PRD): Employed in route scouting and optimization for scalable GMP manufacturing of APIs.

Basic Information

Product Name	(1R,2S)-2-(Methoxymethyl)Cyclobutan-1-Amine Hydrochloride
CAS No.	1820583-44-5
Molecular Formula	C6H14ClNO
Molecular Weight	151.63 g/mol
Synonyms	(1R,2S)-2-(Methoxymethyl)cyclobutan-1-amine hydrochloride; (1R,2S)-2-(Methoxymethyl)cyclobutanamine hydrochloride; trans-2-(Methoxymethyl)cyclobutan-1-amine hydrochloride; (1R,2S)-2-Methoxymethyl-cyclobutylamine hydrochloride; Cyclobutanamine, 2-(methoxymethyl)-, (1R,2S)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (1R,2S)-2-(Methoxymethyl)Cyclobutan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.